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There may also have been problems with sample storage over long periods, especially for plasma homocysteine and vitamin analyses

These include: Inappropriate dosing or frequency Lack of proper diagnosis and monitoring Non-sterile injection technique increasing infection risk Absence of medical supervision for adverse reactions Financial cost without clinical benefit Patients should report any suspected adverse reactions to B12 injections via the MHRA Yellow Card scheme

For instance, while not common, intramuscular injections of vitamin B12 have been reported to cause life-threatening anaphylaxis